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FDA aggressively attacking colloidal silver products to clear the way for a Big Pharma coronavirus VACCINE

FDA aggressively attacking colloidal silver products to clear the way for a Big Pharma coronavirus VACCINE

Postby smix » Sat Jun 06, 2020 1:43 am

FDA aggressively attacking colloidal silver products to clear the way for a Big Pharma coronavirus VACCINE (that will probably kill 100,000 Americans all by itself)
Natural News

URL: https://www.naturalnews.com/2020-04-01- ... virus.html
Category: Politics
Published: April 1, 2020

Description: (Natural News) Companies that sell colloidal silver, which could provide protection against infection with the Wuhan coronavirus (COVID-19), now face possible reprimand from the United States Food and Drug Administration (FDA) for selling “fraudulent products.” The federal agency, which only considers pharmaceuticals to possess any medical benefits, says it recently issued warning letters to multiple firms instructing them to stop suggesting that colloidal silver can in any way help prevent, treat, mitigate, diagnose or cure the Wuhan coronavirus (COVID-19). Instead of focusing on FDA-approved pharmaceuticals, which maim and kill hundreds of thousands of Americans every year, the FDA has instead indicated that it will be “actively monitoring” companies that sell colloidal silver to ensure that they’re not trying to help people avoid infection using this natural alternative. “The FDA is exercising its authority to protect consumers from firms selling unapproved products and making false or misleading claims, including, by pursuing warning letters, seizures, or injunctions against products and firms or individuals that violate the law,” the agency further indicated in an announcement on its “Health Fraud Scams” website.

bill-gates.jpg

In order to make way for an eventual Wuhan coronavirus (COVID-19) vaccine, the FDA is trying to clear out natural things like colloidal silver, vitamin C, zinc, and quinone that threaten to expose the inevitable jab “solution” as unnecessary, and thus fraudulent. The colloidal silver companies targeted by the FDA as part of its crackdown include:
• JRB Enterprise Group Inc. DBA Anti-Aging Bed
• Halosense Inc.
• Bioactive C60/FullerLifeC60 LLC
• Corona-cure.com
• Carahealth
• Xephyr LLC dba N-ergetics
• GuruNanda, LLC
• Quinessence Aromatherapy Ltd
• Vivify Holistic Clinic
• Colloidal Vitality LLC
• The Jim Baker Show
• Herbal Amy Inc.



The science is clear: Colloidal silver is a powerful antiviral
Say what it might about colloidal silver, but the FDA is just plain wrong when it comes to completely discounting it as “fraudulent.” While we can’t say for sure that colloidal silver is a certifiable cure for the Wuhan coronavirus (COVID-19), it remains a scientific fact that silver ions are powerfully antiviral. Long before pharmaceutical drugs even existed, silver was commonly used to kill harmful microbes, whether they be bacteria or viruses. Research into colloidal silver has found that it’s capable of killing more than 650 known pathogens, including the smallpox virus and even HIV (human immunodeficiency virus). Colloidal silver is also capable of attaching to the outer protein shells of viruses and foiling their attempts at attaching to host cells, effectively preventing infection. “Colloidal silver may be a lifeline or just a gimmick – only time will tell,” reports Film Daily. “Clearly there is a lot of positive information about colloidal silver which, in the absence of a mainstream solution, is not something to be dismissed outright.”
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Silver makes antibiotics thousands of times more effective

Postby smix » Sun Jun 07, 2020 1:26 am

Silver makes antibiotics thousands of times more effective
Nature

URL: https://www.nature.com/news/silver-make ... ve-1.13232
Category: healthNews
Published: June 19, 2013

Description: Like werewolves and vampires, bacteria have a weakness: silver. The precious metal has been used to fight infection for thousands of years — Hippocrates first described its antimicrobial properties in 400 bc — but how it works has been a mystery. Now, a team led by James Collins, a biomedical engineer at Boston University in Massachusetts, has described how silver can disrupt bacteria, and shown that the ancient treatment could help to deal with the thoroughly modern scourge of antibiotic resistance. The work is published today in Science Translational Medicine.
“Resistance is growing, while the number of new antibiotics in development is dropping,” says Collins. “We wanted to find a way to make what we have work better.” Collins and his team found that silver — in the form of dissolved ions — attacks bacterial cells in two main ways: it makes the cell membrane more permeable, and it interferes with the cell’s metabolism, leading to the overproduction of reactive, and often toxic, oxygen compounds. Both mechanisms could potentially be harnessed to make today’s antibiotics more effective against resistant bacteria, Collins says.
Resistance is futile
Many antibiotics are thought to kill their targets by producing reactive oxygen compounds, and Collins and his team showed that when boosted with a small amount of silver these drugs could kill between 10 and 1,000 times as many bacteria. The increased membrane permeability also allows more antibiotics to enter the bacterial cells, which may overwhelm the resistance mechanisms that rely on shuttling the drug back out. That disruption to the cell membrane also increased the effectiveness of vancomycin, a large-molecule antibiotic, on Gram-negative bacteria — which have a protective outer coating. Gram-negative bacterial cells can often be impenetrable to antibiotics made of larger molecules. “It’s not so much a silver bullet; more a silver spoon to help the Gram-negative bacteria take their medicine,” says Collins.
Toxic assets
Vance Fowler, an infectious-disease physician at Duke University in Durham, North Carolina, says the work is “really cool” but sounds a note of caution about the potential toxicity of silver. “It has had a chequered past,” he says. In the 1990s, for example, a heart valve made by St. Jude Medical, based in St. Paul, Minnesota, included parts covered with a silver coating called Silzone to fight infection. “It did a fine job of preventing infection,” says Fowler. “The problem was that the silver was also toxic to heart tissue.” As a result the valves often leaked. Before adding silver to antibiotics, “we’ll have to address the toxicity very carefully”, says Fowler. Ingesting too much silver can also cause argyria, a condition in which the skin turns a blue-grey colour — and the effect is permanent. Collins says that he and his colleagues saw good results in mice using non-toxic amounts of silver. But, he adds, there are ways to reduce the risk even further. “We’re also encouraging people to look at what features of silver caused the helpful effects, so they can look for non-toxic versions,” he says.
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Silver Enhances Antibiotic Activity Against Gram-Negative Bacteria

Postby smix » Sun Jun 07, 2020 1:48 am

Silver Enhances Antibiotic Activity Against Gram-Negative Bacteria
Science Magazine

URL: https://stm.sciencemag.org/content/5/190/190ra81
Category: Science
Published: June 19, 2013

Description: Abstract
A declining pipeline of clinically useful antibiotics has made it imperative to develop more effective antimicrobial therapies, particularly against difficult-to-treat Gram-negative pathogens. Silver has been used as an antimicrobial since antiquity, yet its mechanism of action remains unclear. We show that silver disrupts multiple bacterial cellular processes, including disulfide bond formation, metabolism, and iron homeostasis. These changes lead to increased production of reactive oxygen species and increased membrane permeability of Gram-negative bacteria that can potentiate the activity of a broad range of antibiotics against Gram-negative bacteria in different metabolic states, as well as restore antibiotic susceptibility to a resistant bacterial strain. We show both in vitro and in a mouse model of urinary tract infection that the ability of silver to induce oxidative stress can be harnessed to potentiate antibiotic activity. Additionally, we demonstrate in vitro and in two different mouse models of peritonitis that silver sensitizes Gram-negative bacteria to the Gram-positive–specific antibiotic vancomycin, thereby expanding the antibacterial spectrum of this drug. Finally, we used silver and antibiotic combinations in vitro to eradicate bacterial persister cells, and show both in vitro and in a mouse biofilm infection model that silver can enhance antibacterial action against bacteria that produce biofilms. This work shows that silver can be used to enhance the action of existing antibiotics against Gram-negative bacteria, thus strengthening the antibiotic arsenal for fighting bacterial infections.



Silver turns bacteria into deadly zombies
Science Magazine

URL: https://www.sciencemag.org/news/2015/05 ... ly-zombies
Category: healthNews
Published: May 1, 2015

Description: The zombie apocalypse may be more than just a horror story for some bacteria. New research shows that when exposed to a microbe-slaying silver solution, the germs can “go zombie,” wiping out their living compatriots even after death. The results may explain silver's long-lasting antibacterial power and could improve the performance of medical products that keep us safe from harmful pathogens. The use of silver in medicine dates back thousands of years, and scientists have long known that the metal is a potent antibacterial agent. Silver ions perform their deadly work by punching holes in bacterial membranes and wreaking havoc once inside. They bind to essential cell components like DNA, preventing the bacteria from performing even their most basic functions. But silver's "zombie effect" has gone unrecognized—until now. To uncover this grisly mechanism, scientists first killed a sample of the bacterium Pseudomonas aeruginosa using a solution of silver nitrate. Then, they carefully separated the dead bacteria from the silver solution. When they exposed living bacteria to the dead, they witnessed a microscopic massacre: Up to 99.99% of the living bacteria met their doom.

si-zombies.jpg

Using electron microscopy, the researchers imaged the dead bacteria and discovered what caused them to go on their killing spree. Reservoirs of silver nanoparticles had built up in their corpses, indicating that the dead bacteria act like sponges, soaking up silver as they die. The stored silver can leach out to the environment, "especially if the environment contains other sponges for that silver," says chemist David Avnir of the Hebrew University of Jerusalem, the senior author of the new study. "In our case, the other sponge is a living bacterium." The researchers, who published their findings last week in Scientific Reports, also looked at the killing power of the solution they separated from the zombie bacteria. When they started with low concentrations of silver nitrate, the leftover solution wasn’t strong enough to completely wipe out the second round of bacteria. This indicates the bacteria are actually removing silver from the solution, researchers say. When they started out with high concentrations of silver nitrate, the solution retained its killing power through both groups of bacteria, presumably because the first round of bacteria hadn't been able to soak up all of the silver. “This is an important aspect of [silver] that I’ve not seen anyone talk about before,” says molecular microbiologist Simon Silver of University of Illinois, Chicago, who was not involved in the research. "This paper is a new spin on it, to me, and I think rather a good one." The finding could lead to an enhanced ability to control the longevity of silver-based treatments. Doctors and hospitals already rely on an array of silver-infused medical products—from bandages to catheters—to prevent the proliferation of ­bacteria. The metal is commonly used on severe wounds, and coatings on door handles can cut down on germs. Consumers can even buy products to reduce unwanted microbes at home, like silver-infused socks and washing machines that disinfect clothes with silver. "Right now, the dominant idea is, if you want a certain lifetime of antibacterial performance, you have to engineer your device to sort of give off these ions over the full course of the time you want this activity," says nanomaterials chemist Robert Hurt of Brown University, who was not involved in the research. But an understanding of the zombie effect could lead to better designs for such products, Hurt says. For example, engineers may now tailor their products to keep dead bacteria around, fortifying their antimicrobial powers and keeping germs at bay. Zombies might not be so bad after all.
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Proven Colloidal Silver Benefits Or An Unsafe Hoax?

Postby smix » Sun Jun 07, 2020 2:00 am

Proven Colloidal Silver Benefits Or An Unsafe Hoax?
Dr. Axe

URL: https://draxe.com/nutrition/colloidal-silver-benefits/
Category: healthNews
Published: July 19, 2019

Description: If you haven’t heard of colloidal silver, you will soon enough, especially if you’re on the lookout for alternative therapies to common health issues, such as a sinus infection or a cold. Most health food stores and pharmacies stock several brands of colloidal silver, and, of course, you can find a vast amount of information about colloidal silver benefits on the internet. Unfortunately, the information out there is confusing, as many sources have conflicting opinions. On one hand, you’ll run across thousands of personal testimonials about colloidal silver helping people with practically every disease you’ve heard about. You will also stumble upon some well-known health sites that warn consumers about safety concerns. Usually, these sources quote a statement made by the FDA in 1999 claiming that there is no scientific evidence to support the use of colloidal silver. This type of information can confuse even the most savvy natural health enthusiast, which is why I want to lend a helping hand and provide some evidenced-based information to help you make an informed choice about colloidal silver uses and benefits.
What Is Colloidal Silver?
Colloidal silver is a solution of water containing nanometre sized particles of suspended silver. The total silver content is expressed as milligrams of silver per litre of water, or mg/L, which is numerically the same as parts per million (ppm). Silver has been used for at least six thousand years to prevent microbial infections. It has proven to be effective against almost all organisms tested and it has played an important role in the development of radiology and in improving wound healing, according to research out of the University of Cincinnati College of Medicine. Before the invention of the refrigerator, it was common practice to drop a silver coin into a container of milk as a preservative because silver was known to prevent the growth of algae, bacteria and other undesirable organisms. Dating back to ancient times, silver was also a popular remedy to stop the spread of diseases. Its use as a natural antibiotic continued all the way until the 1940s, when modern antibiotics arrived. Today, people obviously don’t need to drop silver coins into their water to experience colloidal silver benefits. All you need to do is carefully take a few drops from a bottle that you buy at the store. According to a report written by Richard Davies and Samuel Etris of The Silver Institute in a 1996, there are three primary ways that colloidal silver can supposedly help heal the body:
- 1. Catalytic Oxidation: Silver naturally holds onto oxygen molecules, which readily react with the sulfhydral (H) groups that surround bacterial and viruses. In turn, this helps block the life-preserving cellular process known as cellular respiration, which is the set of metabolic reactions and processes that take place within the cells of organisms in order to convert biochemical energy from nutrients into adenosine triphosphate (ATP), and then release waste products.
- 2. Reaction with Bacterial Cell Membranes: Silver ions can attach to bacteria cell membranes directly and produce the same respiration-blocking effect.
- 3. Binding with DNA: Shown to literally enter bacteria DNA, up to 12 percent of silver has been detected in Pseudomonas aeruginosa. According to one source, “While it remains unclear exactly how the silver binds to the DNA without destroying the hydrogen bonds holding the lattice together, it nevertheless prevents the DNA from unwinding, an essential step for cellular replication to occur.”
There are basically three types of products that are marketed as “colloidal silver” and these can be categorized as:
1. Ionic silver
Ionic silver solutions are products whose silver content primarily consists of silver ions. Although ionic silver is often marketed as colloidal silver, it’s not true colloidal silver. Because it’s the least expensive to produce, ionic silver is the most popular product in this category. The problem? It simply won’t produce the same benefits that true colloidal silver can.
2. Silver Protein
In order to keep large silver particles suspended, silver protein-based products add gelatin. Silver protein is the second-most popular type of colloidal silver product on the market and can easily be made by adding water to silver protein powder. Again, it’s also often marketed and labeled as colloidal silver, but should not be confused for the real thing. Silver protein is less effective for human use, and you won’t experience the true colloidal silver benefits.
3. True Colloidal Silver
Lastly, true silver colloids don’t contain any protein or other additives, as the vast majority of the silver content consists of nanometre-sized silver particles. This will be the most effective type of colloidal silver.
Is It Safe?
There’s plenty of debate about the potential health risks of colloidal silver. So is it safe to use colloidal silver supplements or products? According to a review published in Environmental Health Perspectives, this is a controversial topic that has contenders on both sides. The review states “despite its widespread use, nanosilver remains a fairly poorly understood material to both regulators and scientists. Consensus remains elusive on subjects as essential as how it behaves in the human body and environment, and the extent to which its use may contribute to bacterial resistance.” Of course, there are two opposing arguments in this debate — what are being called “watchdog groups” that seize on the confusion surrounding colloidal silver side effects and safety, and advocate groups, like the Silver Nanotechnology Working Group, that proclaim its usefulness and safety, noting that most applications use extremely small quantities of silver in their formulas. What the research indicates is that misuse of colloidal silver, or choosing inexpensive, low-quality products that are not true colloidal silver, can cause adverse side effects. For instance, you may have come across warnings about it causing an irreversible condition called argyria, which is when people turn blue. This is usually caused by cheaper products marketed as colloidal silver, such as ionic silver or silver protein. Although the National Center for Complimentary and Integrative Health reports that colloidal silver may cause poor absorption of some drugs, including antibiotics and thyroxine, which is used to treat thyroid deficiency, there is limited research proving that these side effects to colloidal silver exist. There is evidence that using colloidal silver for the treatment of chronic rhinosinusitis is not only effective, but safe when used as a sinus rinse for 10 days. Researchers found that colloidal silver rinses demonstrated a good safety profile with no major adverse events. A lab study published in Particle and Fibre Toxicology found that when the human lung is exposed to silver nanoparticles, it does not cause adverse effects. Lung cells were only sensitive to high silver-ion concentrations. A 2016 study conducted at the University of Michigan found that when oral doses of silver nanoparticles were administered for 28 days, it did not alter the structure or diversity of the animal gut microbiome. This is in contrast to the detrimental effects of broad-spectrum antibiotics. Many advocates are pointing to this study when suggesting the beneficial use of colloidal silver for pets. And in a summary of literature published in Frontiers in Microbiology, researchers concluded that although there are some concerns and controversies related to nano’s safe use in human disease treatment and healthcare, the research that has been done suggests that it can be engineered to “enhance its antimicrobial efficacy, stability, specificity, biosafety and biocompatibility for increased therapeutic benefits and reduced potential side effects.” From the current research, my take is that colloidal silver may work as a potential antimicrobial agent, but it needs to be used appropriately. Only true colloidal silver should be used and studies indicate that short-term use does not cause adverse side effects. One point to consider is that, because colloidal silver is such a potent antibacterial agent, you should be sure to supplement with probiotics during use to be sure that you maintain a proper balance of microflora.
Uses and Benefits
By having a direct effect on cellular respiration, colloidal silver benefits the body in numerous ways, including providing numerous medical uses. There are eight proven healing properties that I consider to be particularly supported by the medical literature.
1. Antibacterial and Antimicrobial
First, colloidal silver’s ability to control antibiotic-resistant superbugs is impressive. While employed at UCLA Medical School in the 1980s, Doctor Larry C. Ford documented over 650 different disease-causing pathogens that were destroyed in minutes when exposed to small amounts of silver. Colloidal silver, unlike its modern prescription antibiotic counterpart, simply doesn’t create resistance or immunity in the organisms that are killed by it. This point cannot be emphasized enough, especially in light of the Centers for Disease Control and Prevention (CDC) recently reporting that more than 2 million people in the U.S. suffer illness every year as a result of antibiotic-resistant infections and 23,000 die from these infections. In addition, a study published in the Journal of Alternative and Complementary Medicine supported ionic colloidal silver as a broad-spectrum antimicrobial agent against both aerobic and anaerobic bacteria, but its activity wasn’t as pronounced against fungi.
2. Wound Care/Skin Health
Robert O. Becker, MD, says that colloidal silver stimulates healing in the skin and other soft tissues. In a research article produced by Pharmacognosy Communications in 2012, it was specifically recommended that certain colloidal silver preparations should be considered for topical use to treat burns, thrush, periodontitis and other conditions. For instance, you can potentially treat ringworm (Tinea capitis) at home with colloidal silver because it’s a potent anti-fungal. Caused by a fungus that lives on the top layer of the skin, ringworm presents as round, scaly patches. It’s contagious and spread by skin contact and by contaminated materials, such as clothing. Colloidal silver benefits many skins conditions as well, including psoriasis and eczema. It’s soothing to scrapes and even repairs tissue damage from burns. In fact, a colloidal silver-based nanogel was successfully used as a dressing for superficial pellet gun wounds in a Journal of Family Medicine and Primary Care study. Such silver nanoparticle-based gel dressings for wounds or even chronic wounds are becoming more common. Topical silver historically was used on burns, but usage stopped after the advent of antibiotics, until the 1960s when it kicked back into popularity. The combination of silver nitrate and sodium sulfadiazine to create SSD cream helped lead to burn recovery in many patients. Applying a silver coating to specialized foam, as part of a wound vacuum system, provides antibacterial activity in vitro. According to research, this technology may assist in preparing infected chronic venous stasis wounds for skin grafting, ultimately leading to better healing.
3. Pink Eye/Ear Infections
Although more research is needed to understand its full potential, the antiviral and antibacterial properties of colloidal silver may allow it to fight some common infections. Pink eye is an inflamed mucous membrane that covers the eyeball and eyelid lining, and it’s primarily caused by a bacterial or viral infection. Colloidal silver can be used for prompt action against this irritating and highly infectious virus and bacteria under the care of your doctor. When applied on the infected eye, the tiny silver colloids are used to pick up the infected cells by attracting them electromagnetically and sending them into the bloodstream to be eliminated. Our modern prescription antibiotic drugs are designed to work against specific classes of bacteria, but ear infections may be caused by multiple classes of bacteria or can even be fungal. In this case, the prescription antibiotic will be useless, whereas colloidal silver is effective regardless of what may be causing your infection. Again, more research is needed to fully understand the mechanisms and safety of colloidal silver for pink eye, ear infections and other bacterial or viral issues, but we do know that it’s a powerful antimicrobial agent that has helped many people treat these conditions.
4. Antiviral
Colloidal silver benefits can be experienced as an anti-viral for HIV/AIDS, pneumonia, herpes, shingles and warts. Colloidal silver suffocates the virus and can even reduce the activity of the HIV virus in AIDS patients. There are also numerous anecdotal accounts of colloidal silver’s efficacy against the hepatitis C virus. According to a study published in the International Journal of Nanomedicine, “silver nanoparticles are capable of reducing viral infectivity, probably by blocking interaction of the virus within the cell.” This might depend on the size and zeta potential of the silver nanoparticles, as smaller-sized particles were able to inhibit the infectivity of the viruses that were analyzed.
5. Anti-Inflammatory
Colloidal silver is also a fantastic anti-inflammatory remedy. Case in point: Researchers at the National Institutes of Health (NIH) studied the effects of inflammation after being treated by colloidal silver, and they found that the inflamed skin of pigs treated with silver experienced near-normal skin after 72 hours, while other treatment groups not treated with silver remained inflamed. Research is beginning to reflect what many people have already known anecdotally for years — that colloidal silver can reduce swelling, speed healing, and boosts cell recovery. More studies on humans are needed to understand the true potential of colloidal silver for inflammation, but what we have already seen is promising.
6. Sinusitis
Widely used to control sinus infections, colloidal silver can benefit people when it’s used as a nasal spray, according to a study published in the International Forum for Allergy and Rhinology in 2014. And a recent 2018 study published in Frontiers in Microbiology found that colloidal silver nasal rinses, when used twice daily for 10 days, are safe and effective for patients with chronic sinusitis. Twenty-two patients completed the study and were given either oral antibiotics with saline rinses twice a day or colloidal silver nasal rinses twice daily. The results indicate that both forms of treatment showed similar improvements in sinusitis symptoms, and using colloidal silver in this manner for ten days was deemed safe. You can purchase a good quality, pure colloidal silver nasal spray product or add a few drops of liquid colloidal silver to a “neti pot.” To apply it directly into your nasal cavity, let it drain down your throat while tilting your head back. Also, it’s important to point out that recent research indicates that hidden infections by pathogens could be a cause of respiratory inflammation associated with common allergies and asthma. Colloidal silver destroys Pseudomonas aeruginosa infections, which may be the reason why airborne allergy sufferers often find such dramatic relief from colloidal silver.
7. Cold/Flu
Some claim that colloidal silver helps prevent all types of flu, including swine flu, as well as the common cold. Few studies have been done to test this clinically, but in 2011 the NIH took 100 children under the age of 12 suffering from the common cold and nasal congestion and assigned them into two groups; the first group was treated with a solution of colloidal silver and beta glucan, and the second group with saline solution. Even though both groups benefited from the treatment, 90 percent of the people in the colloidal silver group completely recovered. And a study published in the Journal of Virological Methods demonstrated that silver nanoparticles have anti-H1N1 influenza A virus activities, especially during the early dissemination stage of the virus.
8. Pneumonia
Our modern drugs have become limited in their efficacy when it comes to fighting bronchitis or pneumonia symptoms. Typically, antibiotics are administered as the first line of defense, but when the pneumonia is viral, antibiotics won’t help in the least. The unique quality of colloidal silver is that it can help regardless of the pathogen, as research indicates it has antiviral and antibacterial properties. Colloidal silver is a remarkable product to help fight against bronchitis and pneumonia when ingested internally, but an even more effective way to utilize it? Simply breathe it into your lungs. This way, the silver directly contacts the germs residing in the lungs, which are causing bronchitis or pneumonia. It’s basically the same thing as using respiratory support, and it works speedily, clearing it up within a couple of days. Now, the most effective method to get the colloidal silver into the lungs is to use a nebulizer. Generally, use one teaspoon approximately three times a day for 10 to 15 minutes.
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Formulations for COVID-19 Treatment via Silver Nanoparticles Inhalation Delivery

Postby smix » Sun Jun 07, 2020 3:40 pm

Formulations for COVID-19 Treatment via Silver Nanoparticles Inhalation Delivery
ResearchGate

URL: https://www.researchgate.net/publicatio ... n_Delivery
Category: Science
Published: June 3, 2020

Description: Abstract
Objectives: For suppression of both viral and bacterial respiratory infections, we present candidate formulations and treatment protocols based on nano-silver colloids (NAgC) by inhalation delivery. Special evaluation is given to Corona virus. We are not aware of any published theoretical or clinical research on medicinal inhalation of silver particles. In this article we lay the grounds for such clinical evaluations to be done, from formulations composition to dosage calculation, delivery method, and clinical safety analysis. The formulations are based on the presently available experimental data. Yet, according to our analysis, the published experiments were all done on sub-optimal NAgC. Hence, following the presented framework, future tests with our recommended more optimized NAgC should lead to improved formulations. From the clinical therapeutic point of view, our treatment formulations may be most effectively applied as a first-line intervention at an early stage of respiratory infections, i.e., when mostly affecting the upper respiratory system and bronchial tree. For example, the proposed formulations could be used to control local outbreaks of COVID-19 via early stage home treatment. We note that similar NAgC dosages also provide anti-bacterial effectiveness. We propose that for hospital ventilator associated pneumonia (VAP), inhalation delivery of NAgC can be implemented prophylactically to lower VAP risk. For completeness, we discuss manufacturing and commercial availability for near term wide public use. The non-development of NAgC anti-viral drug treatments until now is a market failure, likely due to non-patentability, making such developments unattractive for big pharma companies. Unfortunately, the gap between promising academic research and market regulatory approved products has been left to be filled by “alternative medicine” charlatans – giving bad publicity to the whole field. In order to overcome this market failure situation, this article also serves as a proclamation and blueprint for an open-source drug development program to realize it. Potential development parties – academic, clinical, manufacturing, and commercial – are invited to join via the dedicated website noted in our address.
Method: We analyse three core aspects: (a) nano-particle size and material composition options, with special attention to the stabilization (capping) choice of materials, (b) determining the required effective inhibitory concentration (IC) in target respiratory system tissue, (c) the delivery method and associated treatment dosages. Building towards potential clinical evaluation, we discuss the evidence for safety of the proposed treatment based on published tests and guidelines in the EU and USA for inhalation of silver nanoparticles.
Results: The dosage is highly sensitive to the silver nanoparticle size, with 3nm - 7nm being the optimal size, significantly smaller then the ~10nm size of all the best experiments published in the literature. Hence, there is a potential for even better efficacy and/or lower dosage with our recommended NAgC. In manufacturing, PVP stabilization should be avoided, as it lowers the NAgC anti-viral effectiveness significantly (but is still fine for anti-bacterial applications). Effective anti-viral inhibitory concentration (IC) of 10μg/ml is estimated as a reasonable target concentration to achieve in the mucus fluid of the respiratory system. With colloidal silver of 5nm particles, delivering inhalation of standard 5μ diameter droplets aerosol (e.g., using off-the-shelf ultrasonic mesh nebulizers), we assert that IC can be achieved with depositing a total of just 0.33cc of a 30μg/ml NAgC concentration in the bronchial tree. Yet, after accounting for effective deposition fraction (~30%) and due to the fact that active inhalation time is just about 1/3 of the breathing cycle (if common continuous nebulizers are used, rather than breath-activated), a dosage of 3.3ml need to be continuously nebulized for inhalation by the user. We recommend that exhalation through the nose can be implemented as a method to deliver the exhaled fraction of NAgC also to the nasal cavity when the nebulized inhalation is done orally. The required formulations are presently not available on the market but are easy to mass produce in principle. Using off-the-shelf ultrasonic nebulizers and providable OTC colloidal silver formulations, we posit that our suggested method can be used precautionarily at home by anyone feeling the early signs of a potential infection. In addition, due to the anti-bacterial properties of colloidal silver, at similar dosages to the anti-viral formulations, our method can serve in hospital intensive care units (ICU) as a new standard of care prophylactic treatment for ventilator acquired pneumonia (VAP). One of the main factors affecting inhalation antimicrobial delivery is the disease state. Increased mucus production would dilute the drug concentration compared with theoretical estimation based on the available healthy lung mucus volume data. Consequently, as common in antibiotic clinical inhalation therapy, effective treatment dosages are significantly higher than the in-vitro minimal IC (MIC). The earlier the intervention, before significant additional mucus volume is produced, the lower and more predictable the effective dosage. Luckily, for inhalation of NAgC formulations, there is a factor of more than 100x between our theoretically computed MIC and any estimated safety limit in the regulatory literature. Hence, clinical exploration of higher dosages is open for research.
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PDF: Formulations for COVID-19 Treatment via Silver Nanoparticles Inhalation Delivery
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